Current focus of interest is the role of clonal T cell and B cell populations in autoimmunity and cancer, quantitative analysis of individual T cell receptor and antibody repertoires in health and disease. The main goal is to understand the architecture of human adaptive immunity organisation in health and disease, in development and aging. Tools: high-throughput profiling of T cell receptor and antibody repertoires with the use of unique molecular identifiers (UMI), followed by advanced bioinformatics analysis.