Skolkovo Institute of Science and Technology
Dmitry Pervouchine’s group
The computational structural transcriptomics groupThe research is dedicated to all aspects of the biogenesis, structure and function of eukaryotic RNA. The main focus is on understanding the expression regulatory mechanisms of genes involved in disease using methods of bioinformatics, computational genomics and statistical learning.
Prediction of functional RNA secondary structures in eukaryotic genes
Studying the impact of long-range RNA structures on splicing and polyadenylation
High-throughput analysis of long-range interactions in RNA structure via RNA in situ conformation sequencing
Regulation of gene expression through unproductive splicing
Deregulation of unproductive splicing in human disease
Specificity of the interaction of RNA-binding proteins with their targets
Splicing of long non-coding RNAs and their regulatory functions