Skolkovo Institute of Science and Technology
Services of Advanced Mass Spectrometry Core Facility
The identification, characterization and quantification of proteins and proteomes
MALDI-TOF-TOF analysis
MS, LC-MS and LC-MS/MS analysis
Targeted LC-MS/MS (Selected reaction monitoring (SRM), parallel reaction monitoring (PRM))
Quantitative proteomics using isotopically labeled internal standards or Isobaric peptide/protein tags for relative and absolute quantitation (ITRAQ, TMT, etc.), label free protein quantitation
De-novo peptide sequencing
Top down and middle down proteomics
LC/MS analysis of whole protein molecules and its complexes
Sample preparation services (sample fractionation, enrichment, depletion of major proteins, digestion by proteases, etc.)
The identification, characterization and quantification of metabolites
Metabolite mass-spectrometric profiling
Metabolite identification
Metabolome analysis in clinical samples
Service package for confirmation of structural identity of therapeutic protein drugs
Confirmation of a protein primary structure by peptide mapping (>95%)
Determination and mapping of the protein internal and external S-S bonds
The systems-level analysis of glycoproteins, including their sites of glycosylation, and glycan structures
Identification of posttranslational modifications (Met oxidation, deamination)
Complete set of corresponding reports
Service package for De-novo protein sequencing
LC/MS analysis of whole protein molecules
The protein digestion by the set of proteases
Nano-LC-MS/MS of the digested protein
De-novo peptide sequencing
The protein sequence assembly using domestic original computational algorithm
Verification of the obtained results by Edman sequencing of some peptides
Complete set of corresponding reports
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