Skolkovo Institute of Science and Technology
Kazanov Marat's Group
Current research interests of our team lie in several areas of molecular biology and medicine where computational methods are of crucial importance. These include cancer mutagenesis, protease biology, and commensal and pathogenic bacteria genomics. Our latest research projects in the area of the cancer bioinformatics include an investigation of the mechanisms of cancer mutagenesis through the analysis of mutational signatures. These projects centred around the APOBEC family enzymes, the important component of the human innate immune system which also contribute strongly in cancer mutational load.
research areas
Mutational processes in cancer cells:
• Investigating the heterogeneity in the distribution of somatic mutations along the cancer genome
• Studying the 'hotspots' of cancer mutagenesis
Genomics of pathogenic and commensal bacteria:
• Genomic analysis of determinants of antibiotic resistance
• Predicting metabolic phenotypes of human microbiome bacteria
Virology:
• Activation of virus entry into cells by human proteases
• Studying the editing of viral RNA by enzymes of the human immune system
Proteolytic enzymes:
• Developing bioinformatics methods for predicting protease substrates and cleavage sites
Publications
Publications