Kazanov Marat's Group

Current research interests of our team lie in several areas of molecular biology and medicine where computational methods are of crucial importance. These include cancer mutagenesis, protease biology, and commensal and pathogenic bacteria genomics. Our latest research projects in the area of the cancer bioinformatics include an investigation of the mechanisms of cancer mutagenesis through the analysis of mutational signatures. These projects centred around the APOBEC family enzymes, the important component of the human innate immune system which also contribute strongly in cancer mutational load.

Marat

Kazanov

Senior Research Scientist

research areas

Mutational processes in cancer cells:

• Investigating the heterogeneity in the distribution of somatic mutations along the cancer genome

• Studying the 'hotspots' of cancer mutagenesis

Genomics of pathogenic and commensal bacteria:

• Genomic analysis of determinants of antibiotic resistance

• Predicting metabolic phenotypes of human microbiome bacteria

Virology:

• Activation of virus entry into cells by human proteases

• Studying the editing of viral RNA by enzymes of the human immune system

Proteolytic enzymes:

• Developing bioinformatics methods for predicting protease substrates and cleavage sites

Team

Marat

Kazanov

Senior Research Scientist

Publications

Andreeva, N. & Shamanskaya, T. & Gegelia, N. & Abasov, Ruslan & Usman, N. & Kachanov, Denis & Druy, A.. (2022). Comparative genetic profiling of neuroblastoma at the onset vs recurrence or progression of the tumor and determination of the prognostic role of genetic alterations. Pediatric Hematology/Oncology and Immunopathology. 21. 18-30. 10.24287/1726-1708-2022-21-4-18-30.

Semchenkova A, Mikhailova E, Komkov A, Gaskova M, Abasov R, Matveev E, Kazanov M, Mamedov I, Shmitko A, Belova V, Miroshnichenkova A, Illarionova O, Olshanskaya Y, Tsaur G, Verzhbitskaya T, Ponomareva N, Bronin G, Kondratchik K, Fechina L, Diakonova Y, Vavilova L, Myakova N, Novichkova G, Maschan A, Maschan M, Zerkalenkova E, Popov A. Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy. Int J Mol Sci. 2022 Apr 5;23(7):4019. doi: 10.3390/ijms23074019. PMID: 35409391; PMCID: PMC8999738.

Ponomarev GV, Fatykhov B, Nazarov VA, Abasov R, Shvarov E, Landik NV, Denisova AA, Chervova AA, Gelfand MS, Kazanov MD. APOBEC mutagenesis is low in most types of non-B DNA structures. iScience. 2022 Jun 6;25(7):104535. doi: 10.1016/j.isci.2022.104535. PMID: 35754742; PMCID: PMC9213766.